Trichophyton species are the major cause of a significant number of fungal skin infections including, athlete’s foot, tinea capitis (scalp ringworm) and onychomycosis (nail fungus).
HB1275 Topical anti-fungal
HB1275 is a lipohexapeptide with potent antifungal activity against yeast
and filamentous fungi. Safety and efficacy have been demonstrated in dermal
Trichophyton guinea pig infection model. Trichophyton species are the major
cause of a significant number of fungal skin infections including, athlete’s
foot, tinea capitis (scalp ringworm) and onychomycosis (nail fungus). Up
to 70% of Americans have athlete’s foot at any given time, 13% of United
States school children (85% of children in many other countries) test positive
for tinea capitis, and 22-40% of Americans 51-100 years of age have onychomycosis.
Worldwide sales for prescription topical antifungals consequently exceeded
$1.0 billion in 2006, with a similar level of sales for over-the-counter
products addressing these conditions. Our pre-clinical data have shown
that our lead molecules are capable of treating Trichophyton infections
and hold great promise for multiple dermatological indications.
