The innate immunity of vertebrates to microbial invasion is arbitrated by a network of host-defense mechanisms involving both the long-lasting highly specific responses of the cell-mediated immune system and a nonspecific chemical defense system based on a series of broad-spectrum antimicrobial peptides. These peptides are found in a vast array of living organisms, including fish, plants, insects and mammals, providing both a defensive and regulatory role. In man, expression of these peptides on mucosal surfaces of the respiratory and gastrointestinal tracts as well as by the glands of the skin cause the death of numerous pathogens, including viruses, bacteria, protozoa, yeasts, and fungi. In addition, these peptides modulate aspects of inflammation, wound healing and angiogenesis.

Helix BioMedix, Inc. has created an extensive proprietary library of bioactive peptides based upon the diversity of structure, origin and activity of this class of innate immunity element. These include: a novel class of anti-infective, the lipohexapeptides; short bioactive peptides capable of immune modulation and an array of signaling molecules based upon the human body’s own system for responding to injury. Due to the spectrum of activities exhibited by such peptides the Company has been able to tailor their roles to pursue a portfolio of applications including clinical programs such as a broad spectrum topical anti-infective and inclusion in non-clinical products such as skin care.